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Common Side Effects You May Experience Side effects in most patients receiving GLP-1 drugs are usually mild and last only temporarily for a few weeks after initiating therapy

When combined with the metabolic changes that happen while taking GLP-1 medications, the result can be greater fatigue. Scientific American notes that the only way to prevent muscle loss somewhat while losing weight is to combine exercise (particularly resistance exercise and endurance exercise) with a diet higher in protein

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The failure of GLP-1 to stimulate amylase release in guinea pig acini is surprising as all other ways of increasing cAMP in these cells does stimulate amylase release