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ME1 and ME3 require NADP + and ME2 utilizes either NAD + or NADP + for their catalytic activities, thus NADPH can be produced by ME both directly and indirectly through the activity of the NNT that catalyzes the transfer of hydride ions from NADH to NADP + and produces NADPH in mitochondria

The findings cited above are taken from preclinical, animal-model, and in vitro studies and are reported here for research context only

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Probiotics function as bio-antioxidants. (442)