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PloS One 2015;10(3):e0118897

Although Wnt/-catenin signalling is an attractive target evaluated by clinical trials, there is a risk of off-target effects, such as the following: side effects such as diarrhoea, fatigue, nausea dysgeusia, and vomiting 315 kidney injury

Lower doses of Retatrutide produced more modest but still meaningful weight loss, suggesting that clinicians may have flexibility to tailor treatment intensity based on individual patient needs and tolerability

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