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While shifting fat from the liver, heart, muscle, kidneys and pancreatic beta cells to the superficial subcutaneous fat depots where it cannot cause harm does not increase weight, pioglitazone also activates peroxisome proliferatoractivated gamma receptors in the hypothalamus of the brain and sends a signal that the body needs to eat

Standard supplements are often water-soluble, which makes it difficult for them to pass through this fatty gatekeeper

Supported by progress in targeted delivery systems, these multifaceted mechanisms underscore its significant potential for clinical application (80)

About SOUL SOUL was a multicenter, international, randomized, double-blind, parallel-group, placebo-controlled, phase 3b cardiovascular outcomes trial, with 9,650 participants enrolled