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For quality control, we excluded participants who (1) have excess relatedness (more than 10 putative third-degree relatives), (2) have inconsistent information about sex based on genotyping and self-report, (3) have sex-chromosomes not XX or XY, (4) have poor-quality genotyping based on heterozygosity and missing rates, or (5) have withdrawn from UK Biobank

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The Tri-Agonist Mechanism Retatrutides tri-agonist mechanism targets three key receptors: GLP-1, GIP, and glucagon receptors, which complement each other to regulate blood sugar, body weight, and fat metabolism