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Although our synthesis shows increased gastrointestinal AEs and treatment discontinuation related to AEs, these challenges can generally be managed in practice through low-dose initiation, gradual up-titration, and regular monitoring 49

Diabetes Type 1 diabetes is caused by autoimmune-mediated destruction of pancreatic beta-cells [33], and type 2 diabetes is caused by both insulin resistance and relative deficiency of insulin [3436]