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To accomplish some of these objectives, consultation with a specialist is helpful (e.g., movement disorders, physical therapy, psychiatry, and sleep medicine)

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Degeneration of the lower motor neurons in the brainstem and spinal cord and the upper motor neurons in the motor cortex results in gradual denervation of voluntary muscles, leading to disruption of neural networks through a complex set of mechanisms eventually culminating in motor and non-motor symptoms (28)