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While we await more detailed results that may impact further research of semaglutide itself, it is important to investigate therapies that act through these multiple, converging biological pathways. On continuing this line of research, Missling said that more data from the trials is expected at future Alzheimers conferences, and other GLP-1 or dual agonists might still be explored, possibly at higher doses or in preventive trials. Kaeberlein also remained upbeat

To try to overcome this, she teamed up with Walenskys lab, which had previously shown that stapling these small peptides can make them more stable and help them get into cells

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[5] Disruption of these pathways leads to accumulation of homocysteine and methylmalonic acid, metabolic signatures linked to megaloblastic anemia and demyelinating neuropathy