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This process has been replicated by administration of exogenous glutamate receptor agonists including AMPA and kainite to the cochlea (Ruel et al., 2000

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Furthermore, GLP-1RAs might have direct intrarenal effects, such as reductions in sodium reabsorption, hypoxia, oxidative stress, inflammation and apoptosis, increased natriuresis and haemodynamics, and modified neural and reninangiotensinaldosterone system signalling [36, 37]

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