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In cardiac cells, the physical proximity between mitochondria and the sarcoplasmic reticulum (SR, a specific type of ER in heart and skeletal muscle cells) allows the exchange of Ca 2+ in local microdomains, providing rapid Ca 2+ buffering

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When you eat, your gut releases natural GLP-1, which signals your brain to feel satisfied, tells your pancreas to produce insulin, and slows the rate at which food leaves your stomach

The slow start gives the body time to adjust to the medication and minimizes side effects