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Dulaglutide was used in 11 patients (14%), exenatide in three patients (3.8%) and two patients received orally administered semaglutide ( n = 2, 2.6%, PIONEER 7 study participants, NCT02849080) before switching to semaglutide

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The inflammatory marker detected was translocator protein (TSPO), the concentration of which, detected by positron-emission tomography (PET), was found to be increased in several brain areas of depressed subjects, including the prefrontal cortex, anterior cingulate, insula, amygdala and others [87,88], signaling widespread neuroinflammation