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Columbus Instruments, Columbus, OH, USA)

Acknowledgements We thank Alexander Jetter for the discussion on colistin pharmacokinetics, as well as Larissa Govers from Christian Grimms lab for the donation of mouse kidneys from cadavers for the isolation of mitochondria

In the cell experiments, metformin was used at a concentration of 1 mM, simvastatin was used at 2 M, and when combined, the concentrations were 0.5 mM for metformin and 1 M for simvastatin

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