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The rationale went beyond convenience: vortioxetine acts through multiple serotonergic mechanisms simultaneouslyserotonin transporter (SERT) inhibition alongside 5-HT1A agonism, 5-HT3 and 5-HT7 antagonism, and 5-HT1B partial agonismgiving it a pharmacological breadth suited to a drug-induced depression where the precipitating mechanism was unlikely to be purely serotonergic ( Bupropion XL 150 mg once daily was added specifically to address the dopaminergic dimension

Rieckmann P, Albrecht M, Kitze B

After injecting all of the medication, pull the needle out carefully from your skin and cover the site with clean cotton or gauze

Your doctor needs to assess your suitability, screen for contraindications, and ensure appropriate monitoring If you are currently taking Wegovy or any weight loss medication and considering adding another agent