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It does this by: Blocking the release of acetylcholine, a neurotransmitter that can slow heart rate Reducing the excitability of cardiac cells Regulating the flow of potassium and calcium ions across cell membranes Signs of Magnesium Deficiency A magnesium deficiency can show up in different ways, including: Muscle cramps and spasms Fatigue and weakness Heart palpitations and arrhythmias Anxiety and stress Spotting these signs early can help fix the deficiency before it gets worse