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and receiving payment for editorial work from Journal of Child and Adolescent Psychopharmacology outside the submitted work

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Conclusion Whilst severe B12 deficiency has a clear clinical picture with characteristic haematological and/or neurological features, establishing mild or borderline deficiency can be problematic as serum levels are maintained at the expense of tissue concentrations, and therefore serum levels of B12 may be in the low normal or borderline range despite a deficiency

Furthermore, when the ratios of NAD + to NADH in wild-type and mutant strains were compared we detected a significantly lower ratio of NAD + to NADH in the gdh3/gdh3 mutant than in the wild-type strain when incubated in proline medium, while a higher ratio of NAD + to NADH in the gdh3/gdh3 mutant than in the wild-type strain in MM medium (Supplementary Fig