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Generation of PE rat models with different p53 expression levels Female and male SpragueDawley rats aged 68 weeks and weighing 180 ~ 200 g without a mating history were randomized into four groups of eight rats in each group as follows: (1) p53-overexpressing (p53 +/+) group: before pregnancy, 40 mg/kg of the p53 inducer Nutlin-3 was intraperitoneally injected every 2 days for 14 consecutive days, and 125 mg/kg/day L-NAME was intraperitoneally injected on the 7 th day of pregnancy for 7 consecutive days

This is an extremely interesting and novel finding as cutaneous aging is a significant problem faced by the majority of people of any age

(2016) A phase I new approaches to neuroblastoma therapy study of buthionine sulfoximine and melphalan with autologous stem cells for recurrent/refractory high-risk neuroblastoma, Pediatr

World health organization