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doi: 10.1046/j.1365-2796.1999.00513.x 538 DavidASWesselySPelosiAJ

Achieving standardization across the entire workflow from sample collection and preservation to analytical determination constitutes a necessary prerequisite for translating metabolomic research findings into clinical diagnostic and therapeutic decision-making tools

Importantly, nuclear-localized FOXO4-positive Leydig cells in elderly testes showed reduced expression of 3-HSD, a rate-limiting enzyme in testosterone synthesis, implying a connection between nuclear FOXO4 and age-related decline in testosterone production [1]