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Notch signaling In the process of aging, the Notch signaling pathway is activated or inhibited in different tissues due to ligand-receptor imbalance, -Secretase abnormalities and downstream transcription disorders, which drive neurodegenerative diseases, cardiovascular diseases, immune senescence and metabolic disorders

The data warrant further clinical evaluation of LY3298176 for the treatment of T2DM and potentially obesity

Advances in medicine , 2023 , 9946924

In functional assays, GIPR agonism enhanced insulin signaling, augmented glucose uptake, and increased the conversion of glucose to glycerol in a cooperative manner with insulin