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NICE specifically advises against initiating the following medications for chronic primary pain (including fibromyalgia): antiepileptics (including gabapentinoids such as pregabalin and gabapentin), opioids, paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs), benzodiazepines, corticosteroids, and antipsychotics

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Most side effects eventually went away, though the fatigue was still present

Moreover, GLP-1RAs can reverse EndMT induced by high glucose and IL-1 via activating the AMPK pathway, which was evidenced by augmenting an endothelium marker expression (CD31), as well as alleviating mesenchymal markers expression (SM22 (sensitive 22 kDa actin-binding protein of the calponin), vimentin and Snail) [119]