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Together, these emerging agents represent a significant shift in antifungal therapy, expanding treatment options beyond traditional mechanisms, addressing current resistance gaps, and offering improved pharmacological and patient-centered profiles

[1] [4] When B12 is deficient, myelin production is impaired, leading to demyelinationthe breakdown of this protective sheathwhich results in abnormal nerve signalling perceived as pain, tingling, or numbness

The cyclic peptide, Cycle [Pro-Tyr-Pro-Val], isolated from Swiss lactic acid bacteria, exhibited a tyrosinase IC50 of 1.5 mM, with inhibitory activity stronger than that of arbutin, which had an IC50 of 5.0 mM (Kawagishi et al., 1993) (Table 3)