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Similarly, cannabidiol (CBD), which also directly influences endocannabinoid transmission, diminishes ROS accumulation, activates the Nrf2 pathway through NF-kB inhibition and downregulates oxidative enzymes [124, 125]

Li M, Xu S, Geng Y et al (2019) The protective effects of L-carnitine on myocardial ischaemiareperfusion injury in patients with rheumatic valvular heart disease undergoing CPB surgery are associated with the suppression of NF-B pathway and the activation of Nrf2 pathway

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They say you don't get it when you live here for like a few years and then you start getting it a lot