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Considering that a 4.3% increase in FMD is associated with 50% CVD risk reduction [42], the 2.8% improvement in FMD following 4 weeks of CIT+GSH may reduce the risk of cardiovascular events in apparently healthy postmenopausal women

They are not illegal to buy or own, but they are not approved for human use, so are not subject to the quality controls that govern pharmaceutical manufacturing

Therapeutic Use Exemption Program It should be noted that for athletes who have a legitimate medical reason for using a prohibited substance or method that is on the List, they can apply for a Therapeutic Use Exemption (TUE) to determine whether they meet the criteria outlined in the International Standard for Therapeutic Use Exemptions (ISTUE)

A microbiome-based random forest classifier was therefore constructed to predict the TMAO producer phenotype (AUROC = 0.81) which was then validated with an external cohort (AUROC = 0.80)