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The blood pressure load in the daytime and nighttime were significantly increased after liraglutide compared to placebo in patients with eGFR 60 ml/min/1.73 m 2 the changes of arterial pressure were comparable, while the morning surge was significantly reduced after liraglutide compared to placebo

[168] [169] In June 2025, the European Medicines Agency recommended that the product information for semaglutide medicines be updated to include non-arteritic anterior ischemic optic neuropathy (NAION) as a very rare side effect, [170] while the World Health Organization concluded that the risk management plan for semaglutide should be revised to include NAION as a potential risk

Mohamed A, et al

Studies have shown that this treatment can reduce the risk of heart disease, stroke, and other chronic health conditions