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Induction of this biosynthetic pathway enhances intracellular GSH levels and promotes cancer cell resistance to ferroptosis, 142,143 whereas pharmacological inhibition of GSH synthesis by L-buthionine-(S,R)-sulfoximine (BSO), a GCL inhibitor, induces ferroptosis 144

However, a healthy life style, characterized by proper consumption of lipids and carbohydrates that would limit PGC-1 induction, might be a preventive strategy to reduce APAP induced liver damage in human

IL1RAP is an emerging immunotherapeutic target with high selective expression on AML blasts and leukemic stem cells (LSCs)

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