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Artesunate decreases the inflammatory response and alleviates influenza A virus pneumonia by inhibiting the toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-B) signaling pathway (ZHOU et al., 2022)

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The set point between an adaptive response to enzyme induction and a response that ultimately leads to cancer has no universal parameters, as it is influenced by differential species susceptibility, the dose and duration of xenobiotic exposure, and the age and sex of the exposed species or strain, and whether or not the xenobiotic is also mitogenic