does stdei glp-1 really work What the science say about the effectiveness of oral medications? A new clinical trial from Weill Cornell Medicine and @nyphospital included patients who had lost significant weight on an injectable The GLP-1 Knowledge Gap |

To establish the T2DM model, after 8 weeks of HFD (10% lard, 20% sucrose, 2.5% cholesterol, 1% bile salt, and 66.5% regular diet), rats received the intraperitoneal (i.p.) injection of 35 mg/kg STZ (Sigma) after overnight fasting

Effectiveness depends on individual genetics and lifestyle adherence, not whether the medication is branded or compounded

GLP-1RA drugs were associated with significant benefits to neurological and behavioral health, with reduced risks of seizures and addiction to substances such as alcohol, cannabis, stimulants and opioids

For others, the drug improves the kind of test results doctors watch as early warning signs of disease (blood pressure, cholesterol, kidney markers), but the trials that would tell us whether the things we actually care about (heart attacks, strokes, kidney failure) also improve have not yet been reported