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Additional adverse events documented with phentermine include: Overstimulation and tremor Constipation Altered taste perception Abnormal sensations or paresthesia For patients combining phentermine with topiramate, side effect profiles expand to include dizziness and altered taste sensation

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If dosing is too high or continuous without breaks, the body will downregulate its own endogenous pathways and could become dependent or have blunted natural hormone production

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