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Regulation is carried out by binding Nrf2 to a specific DNA sequence known as the antioxidant response element (ARE) found in the promoter regions of genes that encode detoxification enzymes such as NADPH quinone oxidoreductase 1 (NQO1), haem oxygenase 1 (HO-1) and glutathione peroxidase 1 (GPx1), among others [55]

Safe Elimination Bound toxins become water-soluble compounds that are safely excreted through bile and urine

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