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reported that more extreme changes in serum metabolite profiles from days 1 to 4 after severe TBI corresponded to unfavorable clinical outcomes and that serum metabolites on day 4 could better predict outcomes than serum metabolites collected on day 1 [27]

4-Hydroxynonenal (4-HNE), another byproduct of lipid peroxidation, can influence lipogenesis and the uptake of fatty acids into the placenta [27]

Either finding at baseline changes the risk calculus

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