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In patients with and without type 2 diabetes, SGLT2 inhibitors like canagliflozin and dapagliflozin have been demonstrated to dramatically lower the risk of adverse kidney outcomes

Some people use sublingual delivery (powder held under the tongue briefly before swallowing) but there's no strong evidence this meaningfully improves bioavailability for this compound class

AOD-9604 is not FDA-approved for any indication, and all use represents off-label application requiring informed medical decision-making