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Severe complications of this ongoing liver damage include hepatocellular carcinoma (HCC) and liver failure, often necessitating liver transplantation (LT) [3]

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Parallel to the findings from rat liver mitochondria, it has been recently reported that mitochondrial cholesterol enrichment, resulting in mGSH depletion, is a major mechanism of anthrax lethal toxin-induced macrophage cell death (Ha et al., 2012)

Tirzepatide is a dual GIP/GLP-1 receptor agonist with FDA approval for obesity treatment, producing 1521% mean body weight reductions in clinical trials