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Overproduction of hydrogen sulfide, generated by cystathionine beta-synthase, disrupts brain wave patterns and contributes to neurobehavioral dysfunction in a rat model of down syndrome

For most individuals, glutathione serves to support renal integrity by reducing oxidative stress

Moreover, preclinical RF models exhibit significant limitations: UUO and I/R models induce acute severe fibrosis that does not mimic the gradual progression of human CKD-related RF and lacks comorbidities (e.g., diabetes and hypertension) that are common in clinical settings