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For example, one study looking at relatively high doses (0.1-0.3g/kg/day) saw no meaningful improvements in the creatine group compared to placebo in a full suite of exercise measures.18 Another yearlong study, in participants between 49 and 67 taking 0.1g/kg/day, looked at bone density and muscle strength and found only one slight difference favoring the creatine group in a single measure of bone bending strength.37 This evidence points to the likelihood that supplemental creatine is less effective in older populations, though the reasons for this arent firmly established

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But this theory needs more long-term data to confirm

+ - According to published rat pharmacokinetic research quantified via LC-MS/MS detection, oral-administered 5-amino-1MQ (shortened as 5-AMQ) has a mean terminal elimination half-life of roughly 6.90 1.20 hours, while its intravenous counterpart displays a shorter half-life averaging 3.80 1.10 hours