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For staggered titration, separate vials are better

Complement Med Res (2021) 28(6):55770

Rapid and transient inhibition of mitochondrial function following methamphetamine or 3,4-methylenedioxymethamphetamine administration

Peak levels can be delayed by 18 hours Volume of distribution is 0.1 0.2 L/kg Highly protein bound It is metabolised in the liver to multiple active metabolites Resuscitation: Attention to ABC: The need for intubation should be anticipated and performed early in anyone with a declining GCS