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The side effects, which are likely to subside over time, may include: Nausea Diarrhea Constipation Vomiting Heartburn Headaches GERD (Gastroesophageal reflux disease) Starting at low doses may help circumvent these, says Kushner, who also notes that these side effects can usually be alleviated if people eat low-fat foods, smaller portion sizes, and a balanced meal plan

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The patent lapse is expected to give generic competitors a notable head start compared to other regions

In clinical trials, retatrutide has been administered as a subcutaneous injection meaning it is injected into the fatty tissue just beneath the skin once weekly