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He noted that what patients may face if they take more than the recommended dose may be a case of severe side effects that, while not life-threatening, can be nasty. However, the increase of calls to poison-control centres, he believes, could also be due to some patients not being connected to their pharmacist or primary-care provider

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In these phase III studies the DPP-4 inhibitors were examined as monotherapy in drug-nave patients and as add-on to on-going therapy with metformin, sulfonylurea therapy, thiazolidinedione therapy and therapy with exogenous insulin in type 2 diabetes (Table 2)