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Han J, Chen Y, Bao L et al (2013) Anti-inflammatory and cytotoxic cyathane diterpenoids from the medicinal fungus Cyathus africanus

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[1] [2] Systemic symptoms such as fatigue and headache are also recognised, and these may contribute to a flu-like feeling, especially when combined with reduced caloric intake and the body's adjustment to weight loss

Key objectives of pharmacovigilance in clinical trials include: Early identification of adverse drug reactions Continuous monitoring of benefit-risk balance Compliance with global regulatory requirements Protection of trial participants Supporting regulatory decision-making Effective pharmacovigilance systems ensure that safety concerns are detected promptly and that appropriate regulatory actions can be taken when necessary