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Some studies have reported the beneficial effects of incretin mimetics as an effective therapy for hyperphagia and obesity in PWS, considering its potential effects on ghrelin suppression, central appetite suppression (through its action on pro-opiomelanocortin POMC/CART neurons and cocaine- and amphetamine-regulated transcripts in the arcuate nucleus (195),), increased energy expenditure (EE) and stimulation of insulin secretion, which could counterbalance the hypoinsulinemia reported in PWS (196200)
The MDS-UPDRS-3 is the gold-standard physician rating scale used to quantify motor deficits in patients with PD
By promoting a more robust metabolic function, this promising compound could potentially address age-related changes in body composition and metabolism, such as increased fat tissue as fat cells grow larger
This hypothesis aligns with reports of EBV presence in various human cancers [41]
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