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Similarly, in PC12 cell models treated with MPP + , increased ROS, elevated MDA and Fe + levels, and disrupted GSH/GSSG balance reflect the hallmark features of ferroptosis (273)

Percent of patients clustered together using RNA and protein who are also clustered together using RNA or protein alone

These findings position USP13 as a key post-translational regulator, linking deubiquitination of BMAL1 to broader rhythms in physiology and highlighting its potential as a molecular target in circadian dysfunction associated with neurodegenerative conditions