Functional experiments confirmed that knocking down p21 expression in a DMM surgery-induced mouse OA model exacerbated articular cartilage degradation and was accompanied by a significant decrease in GPX4 protein levels in vivo , demonstrating that p21 plays an important anti-ferroptotic role in OA progression by modulating GPX4 stability (Zheng et al., 2024)
Silymarin, a promising pharmacological agent for treatment of diseases, Iranian Journal of Basic Medical Sciences (2011) Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, Phytotherapy Research (2019) Milk thistle, Mount Sinai Milk thistle, Mayo Clinic Milk thistle, National Center for Complementary and Integrative Health Milk thistle, National Library of Medicine (2023) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice
10.1016/j.brainres.2018.09.038 52 KaurH.PatroI.TikooK.SandhirR
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