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4 Antiviral effects of PYC PYC exhibits antiviral activity against a broad range of viruses, including hepatitis C virus (HCV), dengue virus (DENV), classical swine fever virus (CSFV), and human immunodeficiency virus (HIV), among others (Figure 1) ( Substantial insight into PYCs antiviral potential has emerged from in vitro and in vivo studies of HCV

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Riboflavin seems to function as a proteasome inhibitor 43,45 , resulting in the decreased degradation of the NF-B inhibitor, phosphorylated-inhibitor kappa (P-IB), thus preventing nuclear translocation of NF-B and subsequent pro-inflammatory gene activation 46