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Carpal tunnel syndrome symptoms can occur, particularly at higher doses
And as the structure of tirzepatide degrades, its potency decreases
Furthermore, to address concerns related to potential immortal time bias, we performed additional sensitivity analyses, varying the time window for tirzepatide initiation to assess whether different initiation periods influenced the results, and by resetting the index date to the HFpEF diagnosis date for both groups
Retatrutide titration: 1mg to 12mg The retatrutide titration protocol tested in Phase 3 trials follows a five-step escalation: Weeks 1-4: 1mg weekly Weeks 5-8: 2mg weekly Weeks 9-12: 4mg weekly Weeks 13-16: 8mg weekly Week 17 onward: 12mg weekly (maximum dose) The dose doubles at each step (with the exception of the 1mg to 2mg increase), which is a faster escalation rate than either semaglutide or tirzepatide
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