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Semaglutide 2.4 mg was found to have induced an overall mean body weight reduction of 14.9% for patients without diabetes in the STEP 1 trial and 9.6% for patients with diabetes in the STEP 2 trial at 68 weeks 16 , 23 The present study had slightly higher proportions of patients who were female, overweight, had class 3 obesity, or who had baseline comorbidities of hypertension, dyslipidemia, and obstructive sleep apnea compared to the STEP 1 trial

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However, more data is required to determine why some people experience mood improvements while others report increased irritability