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Description

Metformin inhibits advanced glycation end products (AGEs)-induced renal tubular cell injury by suppressing reactive oxygen species generation via reducing receptor for AGEs (RAGE) expression

Severe cardiac damage occurred when given these mice a high-iron diet and hypertrophic cardiomyopathy, with typical features of ferroptosis, which were rescued by administration of Fer-1 [72]

it examines the dosing question on its own terms