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Clinical assessment should include a thorough history and examination to exclude other causes of persistent hiccups, such as gastro-oesophageal reflux disease (GORD), gastric distension, central nervous system pathology, metabolic disturbances, or medication interactions

It leads to decreased inflammation and metabolic health improves

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Furthermore, the inability to measure GSH levels in the CNS has markedly impaired the development of new trials focused on increasing GSH levels