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Both target the melanocortin pathway (MC3R/MC4R), and researchers investigating reproductive function and arousal often use Melanotan 2 when PT-141 is unavailable.

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The most profound conformational change is the sharp kink in the middle of TM6, leading to an outward movement of the intracellular portion of TM6 as measured by C carbon of Lys 6.35b (19.0 , similar to that of other G s -coupled class B receptors)