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showed that intake of alcohol increased serum levels of dehydroepiandrosterone sulphate, testosterone, androstenedione and oestrone compared with non-consumers women (Reference Rinaldi, Peeters and Bezemer36,Reference Shafrir, Zhang and Poole37)

Then, the INT1-Se undergoes two successive [2,3]-sigmatropic rearrangements 44,45,46,47,48,49 to generate the para -amination intermediate ( INT3-Se ), which may readily react with HBr and then rearomatize to the desired product 2a (for details see Supplementary Figs 411)

Blood lipid profile and electrolyte assays Serum samples were assayed for lipid profiles (triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C)) using colorimetric kits from Bio-System Company (Egypt)

This option is handy and portable, but t he results are only rough estimates