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The relative abundance of Bifidobacterium , Lactobacillus , Coprobacillus , Ruminococcus , Prevotella , and Blautia was significantly higher after supplementation, and the abundance of Shigella and Clostridium was significantly lower, meaning that probiotic supplementation regulated the intestinal flora [115]

In fecal samples obtained from PD patients, a significant decrease in short chain fatty acids (SCFAs) has been observed [144]

The involvement of particular amino acids, like arginine, within the CCP is crucial in the targeting procedure as the positively charged guanidine group in arginine can bind to negatively charged components of bacteria cell membranes, helping in the entry and uptake of NPs [213, 214]