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Safety Profile and Adverse Event Data Clinical trial safety data for retatrutide is broadly consistent with what has been reported for GLP-1 and GIP/GLP-1 classes, with a few nuances driven by the addition of glucagon receptor activity

Wong J, Rothmond DA, Webster MJ, Weickert CS (2013)

In 2019, a study found an Association Between High Intakes of Vitamins B6 and B12 From Food and Supplements With [the] Risk of Hip Fracture Among Postmenopausal Women in the Harvard Nurses Health Study. But note, it was only the combined high intake of vitamins B6 and B12