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A number of other clinical trials are underway that address some of the concerns noted in this review: NCT04264897 ( Does Insulin Sensitivity Impact the Potential of Metformin to Slow Aging ) due to be completed in April 2024, which is a randomized, placebo driven, double-blinded Phase 3 study with 148 participants and the objective to compare the effects of metformin on insulin sensitivity and mitochondria function in patients who are insulin-sensitive versus those who are insulin resistant

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Anton SD, Lee SA, Donahoo WT, McLaren C, Manini TM, Leeuwenburgh C et al (2019) The effects of time restricted feeding on overweight older adults

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